MicroScale Thermophoresis: Interaction analysis and beyond
نویسندگان
چکیده
منابع مشابه
Molecular interaction studies using microscale thermophoresis.
Abstract The use of infrared laser sources for creation of localized temperature fields has opened new possibilities for basic research and drug discovery. A recently developed technology, Microscale Thermophoresis (MST), uses this temperature field to perform biomolecular interaction studies. Thermophoresis, the motion of molecules in temperature fields, is very sensitive to changes in size, c...
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Microscale thermophoresis (MST) allows for quantitative analysis of protein interactions in free solution and with low sample consumption. The technique is based on thermophoresis, the directed motion of molecules in temperature gradients. Thermophoresis is highly sensitive to all types of binding-induced changes of molecular properties, be it in size, charge, hydration shell or conformation. I...
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ژورنال
عنوان ژورنال: Journal of Molecular Structure
سال: 2014
ISSN: 0022-2860
DOI: 10.1016/j.molstruc.2014.03.009